Resolving the fibrotic niche of human liver cirrhosis at single-cell level

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better understanding of the cellular and molecular mechanisms involved in disease pathogenesis and enable the discovery of therapeutic targets, here we profile the transcriptomes of more than 100,000 single human cells, yielding molecular definitions for non-parenchymal cell types that are found in healthy and cirrhotic human liver. We identify a scar-associated TREM2+CD9+ subpopulation of macrophages, which expands in liver fibrosis, differentiates from circulating monocytes and is pro-fibrogenic. We also define ACKR1+ and PLVAP+ endothelial cells that expand in cirrhosis, are topographically restricted to the fibrotic niche and enhance the transmigration of leucocytes. Multi-li...

CNC machine tools are highly useful for when you want to take a CAD design and

CNC machine tools are highly useful for when you want to take a CAD design and make real parts as quickly and as easily as possible. Typically, they’re employed in large-scale industrial settings, but CNC machines come in all shapes and sizes. It’s possible to build a useful machine that’s just right to sit on your desk, as [More Than User] demonstrates. The build consists of an aluminium-framed CNC engraver, designed primarily for the production of PCBs. However, it can also handle plastic jobs, and aluminium if run slowly enough. Like most garage CNC projects, it runs with a combination of stepper motors and an Arduino. The cutting area is 16 cm x 16cm – more than enough for most hobby PCBs. There are plenty of interesting details, such as the T-slot bed made from U-section steel bolted together, and the simple probe made from a microswitch. Perhaps most impressive though is the tight precision of the cuts. This is particularly important for PCB work, where otherwise minor issues could cause short or open circuits and make the resulting parts useless. It’s a project that we’re sure will come in handy for [More Than User]’s future projects, and there’s nothing quite like making...

Masco Corp (NYSE:MAS) Stock Holdings Decreased by Pflug Koory LLC

Pflug Koory LLC lowered its stake in Masco Corp (NYSE:MAS) by 15.2% in the 3rd quarter, according to its most recent filing with the SEC. The fund owned 6,959 shares of the construction company’s stock after selling 1,250 shares during the period. Pflug Koory LLC’s holdings in Masco were worth $290,000 as of its most recent SEC filing. Several other institutional investors and hedge funds also recently added to or reduced their stakes in MAS. Marshall Wace LLP bought a new stake in shares of Masco in the 1st quarter valued at approximately $7,664,000. Marshall Wace North America L.P. lifted its stake in shares of Masco by 56,378.5% in the 1st quarter. Marshall Wace North America L.P. now owns 801,995 shares of the construction company’s stock valued at $31,526,000 after purchasing an additional 800,575 shares during the last quarter. B.S. Pension Fund Trustee Ltd acting for the British Steel Pension Fund bought a new stake in shares of Masco in the 1st quarter valued at approximately $472,000. Cleararc Capital Inc. bought a new stake in shares of Masco in the 1st quarter valued at approximately $282,000. Finally, Horizon Investments LLC bought a new stake in shares of Masco in t...

2-shot Injection Molding Market to Perceive Substantial Growth During 2016 – 2024

The analysis and research team at TMR enables customization of report for 2-shot Injection Molding market study. Our experienced research analysts will understand your exact business requirement and provide the most pertinent report for competitive gains.  The 2-shot Injection Molding market intelligence report from TMR is a valuable tool that enables vendors to identify growth avenues, and strategize for launch of products and services. These findings help businesses pave way in a crowded business landscape, and make way into the future with confidence.  To provide this, analysts carried out a succinct analysis of demand drivers, restraints, opportunities, and threats that are likely to influence the 2-shot Injection Molding market over the 2-shot Injection Molding forecast period. These market indicators serve valuable for market stakeholders for business planning, scope of expansion, financial modeling, investment proposition, and to understand competitive dynamics in the 2-shot Injection Molding market over the forecast period.  Request Sample Report @ https://www.transparencymarketresearch.com/sample/sample.php?flag=B&rep_id=18512&source=atm The market research rep...

The introduction of a new generation of the Jeep Wrangler has always been a big deal.

The introduction of a new generation of the Jeep Wrangler has always been a big deal. Rabid enthusiasts of this purebred Jeep model gather scraps of confidential information, obsess over every pixelated spy photograph, and debate the possible consequences of change in their beloved off-road mobility machine. Usually there’s a strong undercurrent of dread to the discussion, and the talk about the introduction of the all-new 2018 Jeep Wrangler has been especially angst-ridden. Car-based, highway-friendly crossovers have been steadily replacing traditional all-terrain, truck-style SUVs. Has this trend compromised the all-new Jeep Wrangler in some way? All this came to mind as we confronted a rocky gully in the breathtaking wilds of New Zealand with a 2018 Jeep Wrangler Rubicon. “That’s the trail?” we thought as we began what looked like an impassable climb. But soon we were making steady progress as the stout suspension and tall wheels of the all-new Wrangler effortlessly articulated over boulders, and the 33-inch BFGoodrich KO2 tires found traction even in the particular brand of slimy mud that they have here in sheep country. Since then we’ve also sa...

Gentherm Reports 2019 Third Quarter Results Nasdaq:THRM

Achieved Highest Gross Margin Rate in Nine QuartersReduced Operating Expenses by over 9% Full-Year Profitability Guidance Maintained Despite Continued Challenging Automotive Environment NORTHVILLE, Mich., Oct. 29, 2019 (GLOBE NEWSWIRE) — Gentherm (NASDAQ:THRM), the global market leader of innovative thermal management technologies, today announced its financial results for the third quarter ended September 30, 2019. Phil Eyler, the Company’s President and CEO, said “I am pleased with our strong performance on profitability in the quarter despite the continued headwinds in the automotive industry. We achieved our highest gross margin rate in nine quarters and delivered the highest quarterly adjusted EBITDA in two and a half years. In Automotive, we secured over $2.5 billion of new awards from top auto makers around the world in the last seven quarters and have consistently outperformed light vehicle production in our key markets. We continue to make progress on ClimateSense®, as evidenced by the successful development project results presented by General Motors and Gentherm at the SAE Thermal Management Systems Symposium.” “However, the production environment continue...

A Low-Key Swedish Island’s Shockingly Modern Architecture

On the tourist mecca of Gotland, tradition is upheld and showiness is frowned upon. What, then, explains its recent crop of contemporary residences? THE DANISH-NORWEGIAN WRITER Aksel Sandemose was a minor literary figure, a notorious crank, when he wrote the 1933 novel containing a set of commandments that would become one of Scandinavia’s defining social texts. “A Fugitive Crosses His Tracks” is a barely veiled send-up of his hometown, Nykobing Mors (renamed Jante) and an uncomfortably close-to-the-bone satire of Nordic conformity. Jante is governed by the “Law of Jante,” rules for living that reflect both Scandinavia’s ethnic homogeneity and its long-held belief that people are happier when both pleasure and pain are spread among all citizens: You shall not believe that you are someone.You shall not believe that you are as good as we are.You shall not believe that you are any wiser than we are.You shall never indulge in the conceit of imagining that you are better than we are.You shall not believe that you know more than we do.You shall not believe that you are more important than we are.You shall not believe that you are going to amount to anything.You shall not laugh at us....

Three recipes from local chefs that make the most of autumn apples | News

With the start of a new season, local restaurants have begun redesigning their menus to make room for fall favorites. For chefs Janina O’Leary of Bacchus Management and Pako Guzman of Steins Beer Garden, an autumn menu is incomplete without a dish featuring apples, whether Granny Smith or Hawaiian. For hungry cooks eager to incorporate the season’s offerings into a dish of their own, O’Leary and Guzman have each prepared recipes that are tangy, sweet and easy to recreate at home. The Post in Los Altos has also shared an apple cocktail recipe to round out the meal. Originally from Texas, O’Leary moved to New York to study at the French Culinary Institute and work at fine dining restaurants there. She also served as the executive chef at LaV, an upscale restaurant in Austin, Texas, before coming to the Bay Area to work as the executive pastry chef at Bacchus Management. She develops desserts for the group’s restaurants, including Selby’s in Redwood City and The Village Pub in Woodside. Her caramel apple tart recipe celebrates the “simple but beautiful” apple, which Bacchus sources from K&J Orchards in Solano County. The tart has...

Understand compatibility, performance, and dimming issues in LED lighting (MAGAZINE)

Dimming LEDs can increase worker productivity, enhance the experience of diners in a hospitality setting, and save energy, but you have to correctly combine controls, drivers, and LED sources. View the Table of Contents and download the PDF file of the complete Spring 2013 issue, or view the E-zine version in your browser. LED-based solid-state lighting (SSL) offers many potential benefits such as energy savings, but the technology comes with new challenges such as compatibility with legacy controls. Moreover, lighting specifiers and designers must understand the unique properties of LEDs to realize optimal performance in installations. Let’s consider the rationale behind dimming and discuss some key questions that can lead to lighting systems that dim to project requirements and yield satisfied customers. The growing popularity of LED light sources is rooted in energy savings, long life, and new fixture options that enable them to be used in almost any application. A 25W LED lamp can replace the light output of a 100W incandescent lamp, deliver a useful lifetime averaging 50,000 hours (compared to 10,000-20,000 hours for fluorescent lamps and 3000 hours for halogen lamps), and ...

BSP delivers another cut in bank reserves by December

Metro Manila (CNN Philippines, October 24) — The Bangko Sentral ng Pilipinas (BSP) has announced a fresh cut in the reserve standard for banks, which comes ahead of a reduction scheduled in November. The BSP’s Monetary Board announced another 100 basis point (bp) reduction in the reserve requirement ratio (RRR) for big banks on Thursday, which would take effect in the first week of December. This means that the reserve standard will drop during the last two months of 2019. The BSP previously announced a 100 bp cut in the required deposit reserves of banks which are due this November. The reserve standard for universal and commercial banks will drop to 14 percent of total deposits by yearend. This effectively leaves the banks with more money to lend, and at a cheaper rate. The BSP also trimmed the mandatory reserves for non-banks with quasi-banking functions, which will stand at 14 percent by yearend. Meanwhile, thrift banks — which focus on retail borrowers mostly for homes, cars, and salary advances — will only have to keep 4 percent of cash deposits in their vaults. The reserve standard for rural banks will stay at 3 percent, with the last adjustment taking effect next m...

Three PCI Express 4.0-capable M.2 slots. 128GB RAM ceiling. Funky “infinity mirror” bling next to CPU

Three PCI Express 4.0-capable M.2 slots. 128GB RAM ceiling. Funky “infinity mirror” bling next to CPU socket. Easy-overclock knob and advanced power delivery. Just four SATA ports. Two PCI Express x1 slots, but both can’t be used at same time. Humdrum, dark PCB. Balky audio utilities in our test build. MSI’s MEG X570 Ace is a premium ATX motherboard designed for latest-gen Ryzen CPUs, brimming with creature comforts (such as an overclocking knob) and the core stuff that sets the X570 chipset apart. It’s a solid effort, but it could use a little more flash and legacy storage support. With this summer’s launch of AMD’s Ryzen third-generation processors and its complementary X570 chipset, it’s time for elite motherboards from the main four makers—Asus, Gigabyte, MSI, and Asrock—to again face off in the feature wars. But there’s the elite, and then there’s the elite. Take MSI’s MEG X570 Ace: This $369.99 ATX-size board, built on AMD’s flagship chipset and packing a heap of overclocking features, is priced in a tier reserved only for serious PC builders and upgraders. But even this board is second silicon banana ...

Save time and avoid stress by keeping keys in a dedicated spot. At 12¾ inches wide

Save time and avoid stress by keeping keys in a dedicated spot. At 12¾ inches wide and 3½ inches high, this key rack and mail holder is perfect for a small space. It’s made of powder-coated steel with wood-capped hooks and a velour-lined bin to hold a phone, letters or sunglasses. Check out the Umbra Estique 5-Hook Organizer for $15.99 at The Container Store in Rockville (301-770-4800; containerstore.com). Contain gloppy galoshes with this great looking copper boot tray. The raised relief design, which helps shoes dry faster, comes in two patterns—pinecones and circles. It measures 34 inches long by 14 inches wide and is priced at $59 at Orvis in Bethesda (301-652-3562; orvis.com). Planks of acacia wood with rustic edges and exposed butterfly joints form a simply elegant modern bench. A black iron shelf provides a sleek contrast and practical storage for shoes. The Yukon natural entryway bench is 56¾ inches long with two color options (natural or gray), and costs $799 at Crate & Barrel in D.C.’s Spring Valley neighborhood (202-364-6100; crateandbarrel.com). A hall tree is a classic entryway or mudroom piece. With a built-in bench, two drawers, hooks for backpacks and dog lea...

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